High quality products to support Pathologists and Biological and Environmental Scientists
GeneAb™ CD13
$204.25 – $919.12Cluster of Differentiation 13 (CD13) is a transmembrane protein that is overexpressed in both hematological and solid malignancies, including Acute Myeloid Leukemia (AML). Although hypogranular variants of AML are difficult to distinguish from other AML subtypes due to the morphology, the diagnosis of this variant is possible through using a panel of CD13, CD16, CD33, CD34, and CD117. Alternatively, a panel of CD13, CD34, CD43, CD68, CD117, CD163, lysozyme, and MPO is very useful for accurately diagnosing myeloid sarcoma and distinguishing it from large cell lymphoma, undifferentiated carcinoma, lymphoblastic lymphoma, malignant melanoma, Burkitt’s lymphoma, extra-medullary hematopoiesis, and inflammation. Since CD13 is expressed in both normal and neoplastic liver tissues, CD13 staining is useful for distinguishing between hepatocellular carcinoma and non-hepatocellular neoplasms.
GeneAb™ HER2/neu
$96.75 – $483.75The HER2/neu (c-erbB-2) proto-oncogene is a transmembrane receptor tyrosine kinase that is clinically indicated in a number of carcinomas. Overexpression of the c-erbB-2 protein has been associated with ductal breast cancer, as well as pulmonary and gastric adenocarcinomas. A correlation between HER2 and p53 has also been documented, as overexpression of both proteins has been associated with early invasion and metastasis in bladder cancer.
GeneAb™ Cytokeratin 7
$102.12 – $451.50Cytokeratin 7 (CK7) is a type II keratin which is present in transitional, ductal, glandular, and biliary duct epithelial cells. Cytokeratin 7 is a useful marker for distinguishing between carcinomas of the lung, breast, endometrium, and urothelia (positive stain) from carcinomas of the colon and prostate (negative stain). Cytokeratin 7 is present in nearly all primary lung adenocarcinomas, and is a useful marker in the differential diagnosis of ovarian neoplasms. Anti-Cytokeratin 7 does not stain intermediate filament.
GeneAb™ CTLA-4
$129.00 – $989.00Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) is a receptor on T helper cells that functions as an immune checkpoint and downregulator of immune responses. Mutations in CTLA-4 are associated with insulin-dependent diabetes mellitus, Hashimoto’s thyroiditis, Graves’ disease, systemic lupus erythematosus (SLE), celiac disease, primary biliary cirrhosis, thyroid-associated orbitopathy, multiple sclerosis, and other autoimmune diseases. The spliced variant of CTLA-4 in SLE is present in the patient’s serum. Haploinsufficiency of CTLA-4 causes the immune system disorder known as CTLA-4 deficiency or CHAI disease (CTLA-4 haploinsufficiency with autoimmune infiltration).
SNPsig® EscapePLEX™ SARS-CoV-2
$1,617.88Product Features
- Rapid detection of specific detection profiles
- High priming efficiency
- Sensitive to < 100 copies of target
- Positive copy number standard curve for quantification
- Accurate controls to confirm findings
- 96 reactions
SNPsig® COVID-19 (20I/501Y.V1+E484K) Identification Kit
$1,612.50- For the detection of the SARS-CoV-2 variants with the 20I/501Y.V1, VOC-21FEB-02 and variants carrying the E484K mutation
- Rapid detection of specific detection profiles
- High priming efficiency
- Sensitive to < 100 copies of target
- Positive copy number standard curve for quantification
- Accurate controls to confirm findings
- 96 reactions, includes master mix
SNPsig® SARS-CoV-2 (VUI-21APR) Identification Kit
$1,612.50- For the detection of the SARS-CoV-2 variants with the VUI-21APR-01 and VUI-21APR-03 (India)
- Rapid detection of specific detection profiles
- High priming efficiency
- Sensitive to < 100 copies of target
- Positive copy number standard curve for quantification
- Accurate controls to confirm findings
- 96 reactions, includes master mix
SNPsig® SARS-CoV-2 (20B/484K) Identification Kit
$1,612.50- Detection of the SARS-CoV-2 variants with the 20B/S.484K mutation, also known as P2
- Rapid detection of specific detection profiles
- High priming efficiency
- Sensitive to < 100 copies of target
- Positive copy number standard curve for quantification
- Accurate controls to confirm findings
- 96 reactions, includes master mix