GeneAb™ CD73

Cluster of Differentiation 73 (CD73), also known as Ecto-5′-Nucleotidase (ecto-5′-NT), is a cell surface enzyme found in most tissues. CD73 catalyzes the breakdown of AMP to adenosine, thereby modulating inflammatory and T-cell responses. Reports have implicated CD73 expression in tumour progression and carcinogenesis, as CD73 is a key regulatory molecule in the proliferation, migration, and invasion of cancer cells in vitro, as well as tumour angiogenesis and tumour immune escape in vivo. Due to this key involvement in cancer, CD73 has become an appealing target for cancer immunotherapy. CD73 expression has also been linked to favourable prognosis in breast carcinoma.