GeneAb™ Thymidylate Synthase

$125.00$620.00

Thymidylate Synthase (TS) is a crucial enzyme responsible for the synthesis of 2′-deoxythymidine-5′-monophosphate (dTMP) a precursor for thymidylate which is necessary for DNA replication and repair from 2′-deoxyuridine-5′-monophosphate (dUMP). In terms of cancer, TS is an important target for cancer treatment as the inhibition of TS and therefore nucleotide synthesis necessary for cell growth has shown to be a vital part for successful treatment against colorectal, pancreatic and breast cancers.

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Description

Specifications

CloneIHC697
SourceMouse Monoclonal
Positive ControlColon Cancer
Dilution Range1:100 – 1:200

IFU & SDS

References

  1. Rose, M. G., Farrell, M. P., & Schmitz, J. C. (2002). Thymidylate synthase: a critical target for cancer chemotherapy. Clinical colorectal cancer, 1(4), 220-229.
  2. Peters, G. J., Backus, H. H. J., Freemantle, S., Van Triest, B., Codacci-Pisanelli, G., Van der Wilt, C. L.& McLeod, H. L. (2002). Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1587(2-3), 194-205..

Additional information

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0.1ml C, 1ml C, 7ml P, 25ml P