GeneAb™ p16



The p16 (p16INK4A) protein is a cyclin-dependent kinase inhibitor that plays an important regulatory role in the cell cycle. By controlling the transition between the G1 and S phases through regulation of retinoblastoma protein, p16 decelerates cellular differentiation and therefore acts as a tumor suppressor, making it the key marker in several human cancers including head and neck cancer, perianal lesions, melanomas, gliomas, lymphomas, and some types of leukemia. p16 is also clinically indicated in carcinomas of the esophagus, pancreas, lung, biliary tract, liver, colon, and urinary bladder.

SKU: IHC063-2 Categories: ,



SourceMouse Monoclonal
Positive ControlCervical Cancer, Normal Pancreas, Normal Tonsil
Dilution Range1:100 – 1:400



  1. Sano T, et al. Am J Pathol. 1998; 153:1741-8.
  2. Agoff SN, et al. Mod Pathol. 2003; 16:665-73.
  3. Negri G, et al. Am J Surg Pathol. 2003; 27:187-93.
  4. Klaes R, et al. Int J Cancer. 2001; 92:276-84.
  5. Klaes R, et al. Am J Surg Pathol. 2002; 26:1389-99.
  6. Negri G, et al. Virchows Arch. 2004; 445:616-20.

Additional information

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0.1ml C, 1ml C, 7ml P, 25ml P