Brucella abortus


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Product features

  • Exceptional value for money
  • Rapid detection of all clinically relevant subtypes
  • Positive copy number standard curve for quantification
  • Highly specific detection profile
  • High priming efficiency
  • Broad dynamic detection range (>6 logs)
  • Sensitive to < 100 copies of target
  • Accurate controls to confirm findings
SKU: B.abortus-standard Category: Tag:

Brucella abortus is an intracellular, blood-borne parasite. It is a Gram-negative coccobacillus that causes an infectious and contagious disease called Brucellosis. The disease primarily affects cattle but it can also be transmitted to humans from infected animals and consuming their products. The disease can lead to great economic loss especially in the dairy and agricultural industry. The Brucella abortus genome contains two DNA chromosomes in a circular confirmation; the first chromosome is approximately 2.1 Mb and the second chromosomeisapproximately1.2Mb.Unusuallyitdoesnotcontainanyplasmidsorgenomic islands that relate to pathogenicity and lacks many other genes that code for common virulence factors including capsules, fimbriae, exotoxins, cytolysins, resistance forms, or antigenic variation. Themostcommonmodeoftransmissiontohumansisthroughtheingestionofunpasteurized milk and cheese products as the bacteria are present in the milk glands of infected female cows. In cattle transmission can also be through ingestion but in addition, the bacteria can persist in the reproductive tracts of males, namely seminal vesicles, ampullae, testicles, and epididymides, allowing sexual transmission. In humans the bacteria enter macrophages by phagocytosis and then live in compartments of vacuolar space along the endoplasmic reticulum.Theypersistbyinhibitinghostapoptosisandgoontoformchronicdiseasecausing lesions in the liver, spleen, bone marrow and kidneys. In cattle the bacteria additionally infect the trophoblast epithelial cells, which provide nutrition to the embryo. The trophoblast cells eventually lyse, releasing further bacteria into the blood stream of the embryo. The B. abortus cells in the blood stream go on to colonize the placenta and fetus in pregnant female cows, resultinginabortionofthefetus.Abortioncanalsoresultfrominsufficientanti-Brucellaactivity in the amniotic fluid. In humans, the disease can be either acute or chronic and some of the symptoms include fluctuating fever, chills, sweating, headache, muscle pain and weight loss. Once a person becomes infected they are prescribed a combination of tetracycline and streptomycin for 3-6 weeks. In cattle, additional symptoms include arthritic joints and retained after-birth.

Brucella abortus Manual