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GeneAb™ p63

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p63 is a tumor suppressor protein that is very similar to p53 in structure and function, while being homologous to p73. p63 is important in development and differentiation, and has been identified as a useful marker for distinguishing between lung squamous cell carcinomas and adenocarcinomas. Anti-p63 is also used to differentiate between benign and malignant prostate and breast lesions, due to its labeling of the nuclei of myoepithelial cells in both tissue types.

SKU: IHC063 Categories: , ,
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Specifications

Clone IHC063
Source Mouse Monoclonal
Positive Control Skin, squamous cell carcinoma, Prostate
Dilution Range 1:100 – 1:200

IFU & SDS

References

  1. Yang A, et al. Mol Cell. 1998; 2:305-16.
  2. Signoretti S, et al. Am J Pathol. 2000; 157:1769-75.
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  5. Werling RW, et al. Am J Surg Pathol. 2003; 27:82-90.
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  7. Iacono ML, et al. J Thorac Oncol. 2011; 6:473-81.
  8. Mukhopadhyay S, et al. Am J Surg Pathol. 2011; 35:15-25.
  9. Conde E, et al. PLoS One. 2010; 5:e12209.
  10. Uke M, et al. Cytopathology. 2010; 21:56-63.