GeneAb™ BSEP

$145.00$670.00

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Bile Salt Export Pump (BSEP) is a member of the ATP-binding cassette (ABC) transporters, which mediates the transport of bile acid, taurocholate and other cholate conjugates across the hepatocyte canalicular membrane into the canaliculus. BSEP is associated with progressive familial intrahepatic cholestasis type 2 (PFIC2) and benign recurrent intrahepatic cholestasis type 2 (BRIC2). PFIC2 caused by mutations in the BSEP gene increases the risk of hepatocellular carcinoma in early life.

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Specifications

Clone IHC512
Source Mouse Monoclonal
Positive Control Liver
Dilution Range 1:100 – 1:200

IFU & SDS

References

  1. Strautnieks S, et al. Nature Genetics. 1998; 20:233–8.
  2. Noé J, et al. Gastroenterology. 2002; 123:1659–66.
  3. Arrese M, et al. Pflügers Archiv. 2004; 449:123–31.
  4. Jansen PL, et al. Gastroenterology. 1999; 117:1370–9.
  5. van Mil SW, et al. Gastroenterology. 2004; 127:379–84.
  6. Knisely AS, et al. Hepatology. 2006; 44:478–86.
Select Volume

0.1ml C, 1ml C, 7ml P, 25ml P