GeneAb™ p53

$50.00$180.00

p53, also known as tumor protein 53 or TP53, is a tumor suppressor and transcription factor that functions in a number of anti-cancer activities including DNA repair, cell-cycle arrest, and apoptosis in response to DNA damage or other stressors. Mutations in p53 are linked to a number of malignant tumors, including those of the breast, ovarian, bladder, colon, lung, and melanoma. Anti-p53 staining has been used to detect intratubular germ cell neoplasia, and also to distinguish between uterine serous carcinoma and endometrioid carcinoma.

Clear

Description

Specifications

CloneIHC053
SourceMouse Monoclonal
Positive ControlColon Carcinoma
Dilution Range1:100 – 1:200

IFU & SDS

References

  1. Stoehlmacker J, et al. Oncol. 2003; 30:10-16.
  2. Gallo O, et al. Hum Pathol. 2002; 33:708-714.
  3. Sano H, et al. Cancer Res. 1995: 55:3785-9.
  4. Denkert C, et al. Cancer. 2003; 97:2978-87.
  5. Sheehan KM, et al. Hum Pathol. 2003; 34:1242-1246.
  6. Moore BE, et al. Appl Immunohistochem Mol Morphol. 2001; 9:203-6.
  7. Mauri FA, et al. Int J Oncol. 1999; 15:1137-47.
  8. Caffo O, et al. Clin Cancer Res. 1996; 2:1591-9.
  9. Bebenek M, et al. Anticancer Res. 1998; 18:619-23.
  10. Midulla C, et al. Anticancer Res. 1999; 19:4033-7.
  11. Zen ZS, et al. J Clin Oncol. 1994; 12:2043-50.
  12. Quinlan DC, et al. Cancer Res. 1992; 53:4828-31.
  13. Alexiev BA, et al. Gen Diagn Pathol. 1997; 142:271-9.

Additional information

Select Volume

0.1ml C, 1ml C, 7ml P, 25ml P